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Interactions

A. Top Drug-Drug Interactions:

1.Nitrates (e.g., nitroglycerin, isosorbide dinitrate): Cialis and nitrates both lower blood pressure. Taking them together can cause a significant and potentially life-threatening drop in blood pressure (hypotension), leading to dizziness, fainting, or even heart attack or stroke. It is contraindicated to use Cialis with nitrates or recreational "poppers" (amyl nitrites).

2.Alpha-blockers (e.g., prazosin, terazosin, tamsulosin): Both Cialis and alpha-blockers relax blood vessels, which can lead to excessive blood pressure reduction when used together. This may result in dizziness, fainting, or orthostatic hypotension (a sudden drop in blood pressure when standing). If needed, your doctor may adjust the dosage or recommend spacing the medications.

3.Other antihypertensive drugs (e.g., atenolol, propranolol, enalapril, lisinopril): Cialis can enhance the blood-pressure-lowering effects of these medications. While this interaction is usually less severe than with nitrates or alpha-blockers, it can still cause dizziness or fainting in sensitive individuals. Close monitoring of blood pressure is recommended.

Other Drug-Drug interactions:

  • Ketoconazole, itraconazole (used to manage fungal infection)
  • Protease inhibitors (used to manage HIV infection) Ex. ritonavir, lopinavir
  • Phenobarbital, phenytoin, carbamazepine (medicines used for fits)
  • Rifampicin, erythromycin, clarithromycin (medicines used for bacterial infections)
  • Other medicines used to improve blood flow to the penis (Ex. sildenafil)

B. Drug-Food Interactions:

Cialis (tadalafil) can interact with certain foods and beverages, potentially altering its effectiveness or increasing the risk of side effects. Here are the key drug-food interactions to be aware of:

  1. Grapefruit and Grapefruit Juice: Grapefruit can increase the levels of tadalafil in your blood by interfering with its metabolism. This may amplify side effects, such as headaches, dizziness, or low blood pressure. Avoid consuming grapefruit or grapefruit juice while taking Cialis.
  2. Alcohol: Drinking alcohol with Cialis can enhance the blood pressure-lowering effects of the medication, leading to symptoms like dizziness, lightheadedness, or fainting. Limiting alcohol intake is recommended while using Cialis.
  3. High-Fat Meals: While Cialis can be taken with or without food, consuming it with a high-fat meal may delay its onset of action. Opt for lighter meals if rapid effectiveness is needed.
  4. Caffeine: Though not a direct interaction, combining Cialis with high caffeine intake might worsen side effects like headaches or increase heart rate in sensitive individuals.
Alistams Cialis is a PDE5 inhibitor which works by widening blood vessels and increasing blood flow to the penis. This increases blood flow is vital for healthy sexual function. Alistams Cialis amend the way blood pressure is lower in individuals who are sensitive to medications such as Cialis or alpha-blockers. This helps prevent symptoms such as dizziness, lightheadedness, or fainting, which can be dangerous.Cialis and Tadalafil are used to manage blood pressure (hypertension), while Tadalafil is used to treat pulmonary arterial hypertension, a condition where blood vessels are narrowed and/or reducing in size.

Side Effects:When using Cialis and Tadalafil, some side effects can be more than you canORTIMAL. COM-common. Tell your doctor about all the medications you are taking, including prescription drugs, nonprescription medications, and recreational drugs.

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Cialis has been shown to cause some mild side effects. Talk to your health care provider if these do not go away within a few days. If you begin to experience more serious reactions, seek medical attention immediately.

Common side effects reported from Cialis use include:

  • Headache
  • Indigestion
  • Heartburn
  • Upset stomach
  • Gas
  • Nausea
  • Flushing

More severe side effects include:

  • Painful erections or erections that last longer than 4 hours
  • Sudden loss of vision
  • Sudden loss of hearing
  • Ringing in the ears
  • Chest pain
  • Shortness of breath
  • Painful urination
  • Increased urination frequency
  • Fainting
  • Dizziness
  • Skin rash
  • Hives
  • Facial swelling

If you experience any of these side effects, seek medical attention immediately. These are symptoms of a severe adverse reaction to this medication that require immediate treatment.

As with all prescription medications, inform your doctor of any medical conditions you currently manage. Tell them about any and all medications, prescription drugs, and supplements you are taking before starting treatment with Cialis. Cialis can interact with bodily substances, causing potentially serious adverse reactions.

Specifically, you should inform your health care provider of any alpha-blocker, antifungal, HIV protease inhibitor, or high blood pressure medication you are taking. Remember to mention any herbal products you use, especially St. John’s wort.

In addition, let your doctor know if you have recently had heart surgery or experience chest pain during sex. If you experience any changes in your heartbeat or chest pain during sex, contact your health care provider immediately.

Read more about Cialis's effects and how it can affect your health in more detail.Back pain and joint pain is more common with Cialis use. However, it's not known if Cialis can interact with these side effects.
  • Sudden vision loss
  • Sudden hearing decrease
  • Sudden lightheadedness
  • Sudden chest pain
  • Sudden priapism (an unexpected prolonged erection). If you experience any serious symptoms, such as an erection that doesn't go away, seek medical attention immediately.
  • Tell them if you're currently taking nitrates or warfarin type medications for pain. Cialis can interact with these products, causing a drop in blood pressure. Additionally, inform your health care provider if you are taking any other medications, including non-prescription medications that do not require a prescription.

    If you experience changes in heartbeat or chest pain during sex, contact your health care provider immediately.

    In addition, let your doctor know if you are pregnant or plan to become pregnant. We willochdhesignallylittleoubtedlyhaveprobablesays when taken with Cialis. Cialis can cause potentially serious side effects including:

    • Back pain

    If you experience any side effects, seek medical attention immediately.

    If you experience any changes to your heartbeat or chest pain during sex, contact your health care provider immediately.

    In addition, let your doctor know if you are breastfeeding.

    Description

    Cialis (tadalafil) is a phosphodiesterase type 5 (PDE5) inhibitor. It works by relaxing the blood vessels in the penis, thereby increasing blood flow through the penis during sexual stimulation. This increase in blood flow causes an erection.

    Benefits

    Cialis (tadalafil) is a phosphodiesterase type 5 (PDE5) inhibitor that relaxes the blood vessels in the penis. This allows for increased blood flow, resulting in an erection.

    How it works

    Cialis (tadalafil) works by inhibiting the enzyme PDE5, which is found in the smooth muscle cells lining the blood vessels of the penis. By inhibiting PDE5, cGMP levels in the blood vessels are increased, which in turn helps relax the blood vessels and allows for an erection. This increases blood flow and helps to achieve and maintain an erection.

    Usage

    Cialis (tadalafil) should be taken as advised by your doctor, usually once daily. The typical dosage is one tablet (50mg) taken approximately one hour before sexual activity, but may be taken with or without food. The maximum recommended dose is 100mg per day.

    Side effects

    Cialis (tadalafil) may cause side effects, although not everyone experiences them. These side effects may be mild and temporary, but if you experience serious side effects, seek immediate medical attention.

    Precautions

    Before taking Cialis (tadalafil), tell your doctor if:

    • You have heart problems, high or low blood pressure, diabetes, high cholesterol, or smoking
    • You are taking nitrates for chest pain or heart problems, or angina
    • You are planning to have a heart attack, stroke, or heart failure, or if you have high blood pressure

    Possible side effects

    Most side effects do not require any medical attention and tend to diminish over time. However, if you experience serious side effects, seek immediate medical attention.

    Drug interactions

    Cialis (tadalafil) may interact with some medicines, including:

    • Nitrates
    • Alpha-blockers
    • Antifungal medicines
    • Certain antidepressants

    Cialis (tadalafil) may decrease the effect of other medicines, such as:

    • Blood pressure medicines
    • Diuretics
    • Antiarrhythmic medicines

    Talk to your doctor before taking Cialis (tadalafil) if you have any of the following medical conditions:

    • Kidney disease
    • Liver disease
    • Stomach ulcer
    • Bleeding disorders
    • Seizures
    • Athlete’s foot

    You should avoid sexual activity with any of these conditions as it may lead to problems with your heart and could increase your risk of heart attack, stroke, and other serious side effects.

    Pregnancy and breast feeding

    Cialis (tadalafil) should not be used by women who are pregnant or may become pregnant. It should be avoided by breastfeeding women as it can cause side effects on their infants.

    Interactions

      Some medicines may affect how Cialis (tadalafil) works. Tell your doctor about all the medicines you take, even medicines that might not be available over the counter (e.g., medicines that you don’t buy without a prescription).